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Related Concept Videos

Cancer02:18

Cancer

53.2K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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Tumor Progression02:07

Tumor Progression

7.1K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.8K
Metastasis02:30

Metastasis

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
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mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

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The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
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Related Experiment Video

Updated: Dec 21, 2025

Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer
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Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer

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[Advances in molecular oncologic pathology].

Lei Chen1

  • 1State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, 510060, P. R. China. drleichen@gmail.com

AI Zheng = Aizheng = Chinese Journal of Cancer
|January 16, 2007
PubMed
Summary

Molecular oncologic pathology integrates molecular biology and traditional pathology for cancer diagnosis and treatment. This field uses molecular evidence to predict tumor behavior and guide personalized cancer care.

Area of Science:

  • Molecular pathology
  • Oncology
  • Genomics

Context:

  • Traditional pathology relies on morphology.
  • Molecular oncologic pathology integrates molecular biology with oncologic pathology.
  • This new discipline uses molecular evidence for cancer assessment.

Purpose:

  • To review the basic concepts and theories of molecular oncologic pathology.
  • To illustrate clinical applications through case studies.
  • To explain the role of molecular oncologic pathology in cancer management.

Summary:

  • Molecular oncologic pathology complements traditional methods by using molecular evidence.
  • It aids in predicting tumor biological behavior and guiding therapy.
  • The review covers fundamental principles and practical applications.

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Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
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Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

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Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer
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Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
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Impact:

  • Assists clinicians in cancer diagnosis and treatment selection.
  • Improves prognostication of cancer patient outcomes.
  • Enhances cancer prevention strategies through molecular insights.