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Related Experiment Video

Updated: Jul 17, 2026

Determination of High-affinity Antibody-antigen Binding Kinetics Using Four Biosensor Platforms

Determination of High-affinity Antibody-antigen Binding Kinetics Using Four Biosensor Platforms

Published on: April 17, 2017

Portable 24-analyte surface plasmon resonance instruments for rapid, versatile biodetection.

Timothy M Chinowsky¹, Scott D Soelberg, Paul Baker

¹timchinowsky@alum.mit.edu

Biosensors & Bioelectronics

|January 16, 2007

Summary

We developed a compact, portable surface plasmon resonance (SPR) biosensor for rapid, multi-analyte detection in environmental and defense applications. This rugged instrument enables simultaneous screening of up to 24 substances in the field.

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A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions

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Published on: November 23, 2015

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Determination of High-affinity Antibody-antigen Binding Kinetics Using Four Biosensor Platforms

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Published on: April 17, 2017

A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions

A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions

Published on: November 23, 2015

Area of Science:

Biosensing
Instrumentation
Environmental Monitoring

Background:

Field deployment of surface plasmon resonance (SPR) biosensors is limited by the lack of rugged, portable, high-performance instrumentation.
Applications include environmental monitoring and defense, such as detecting biological warfare agents.

Purpose of the Study:

To develop a compact, multi-analyte SPR instrument for field use.
To overcome the limitations of current SPR instrumentation for real-world applications.

Main Methods:

Development of a 3 kg SPR instrument using Texas Instruments' Spreeta sensing chips.
Incorporation of automated valves and pumps for computer-controlled sample injection, rinsing, and reagent treatment.
Simultaneous monitoring of up to 24 sensing areas on eight sensor chips per instrument.

Main Results:

The instrument reports refractive index (RI) values every second with a noise level of 1-3 x 10(-6) RI units.
Demonstrated detection of six distinct analytes, from small molecules to whole microbes, in a single experiment.
The device is housed in a clamshell enclosure (28 cm x 22 cm x 13 cm).

Conclusions:

The developed compact SPR instrument meets the need for rugged, portable, high-performance instrumentation for field applications.
This technology enables simultaneous screening of multiple analytes, enhancing detection capabilities for environmental and defense purposes.