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Updated: Jul 17, 2026

Preparation of Tunable Extracellular Matrix Microenvironments to Evaluate Schwann Cell Phenotype Specification
Published on: June 2, 2020
The role of extracellular matrix in CNS regeneration
1Case Western Reserve University School of Medicine, Department of Neurosciences, 2109 Adelbert Road E-658, Cleveland, Ohio 44106, USA.
Abstract:
Chondroitin sulfate proteoglycans are the principal inhibitory component of glial scars, which form after damage to the adult central nervous system and act as a barrier to regenerating axons. Recent findings have furthered our understanding of the mechanisms that result in a failure of regeneration after spinal cord injury and suggest that a multipartite approach will be required to facilitate long-distance regeneration and functional recovery.
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