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Novel Object Recognition and Object Location Behavioral Testing in Mice on a Budget

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A new test for long-term spatial memory using an operant chamber in mice.

Sebastien Delcasso¹, Yannick Jeantet, Yoon H Cho

¹Laboratory of Cognitive Neuroscience, CNRS UMR 5106, Avenue des Facultés 33405 Talence Cedex, France.

Behavioural Brain Research

|January 16, 2007

Summary

Mice demonstrated improved spatial memory in a novel operant chamber task. Memory savings increased with longer retention intervals, and performance was affected by scopolamine.

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Area of Science:

Neuroscience
Behavioral Science
Cognitive Science

Background:

Developing automated behavioral tasks is crucial for studying mouse cognition.
Standardized tasks are needed for high-throughput screening of genetically modified mice.

Purpose of the Study:

To develop and validate a new, automated spatial memory task for mice.
To assess the impact of retention interval length and scopolamine on spatial memory.

Main Methods:

A new rectangular operant chamber with spatially distinct nose poke holes was designed.
A successive reversal discrimination paradigm was employed for a spatial memory task.
Mice (C57BL/6) underwent training, followed by testing after varying delay intervals (5 min to 24h).

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Main Results:

Mice showed significant memory savings during the test phase, indicating learning.
Memory savings were dependent on the retention interval length.
Scopolamine administration impaired discrimination performance in a dose-dependent manner.

Conclusions:

The developed spatial memory task is simple, requires minimal resources, and is suitable for high-throughput behavioral characterization.
This task effectively probes cognitive and mnemonic capabilities in mice.
The findings highlight the task's sensitivity to pharmacological manipulation, relevant for drug discovery.