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Related Experiment Videos

Chronic wasting disease.

Christina J Sigurdson1, Adriano Aguzzi

  • 1Universitäts Spital Zürich, Institute of Neuropathology, Department of Pathology, Schmelzbergstrasse 12, Zürich, Switzerland. csigurd@lamar.colostate.edu

Biochimica Et Biophysica Acta
|January 16, 2007
PubMed
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Chronic wasting disease (CWD), a wildlife prion disease, has spread beyond its known locations in the US and Canada. Understanding CWD transmission and genetic factors is crucial for managing this challenging wildlife disease.

Area of Science:

  • Veterinary Medicine
  • Wildlife Ecology
  • Prion Diseases

Background:

  • Chronic wasting disease (CWD) is the only known prion disease affecting free-ranging wildlife.
  • Historically, CWD was thought to be geographically limited to Colorado and Wyoming, USA.
  • Recent surveillance indicates a broader distribution across North America.

Purpose of the Study:

  • To document the expanding geographic range of Chronic Wasting Disease (CWD).
  • To highlight the distribution of PrP(Sc) aggregates in CWD-affected cervids.
  • To discuss the implications of genetic polymorphisms on CWD susceptibility and disease management.

Main Methods:

  • Expanded wildlife surveillance for CWD.
  • Pathological examination of PrP(Sc) aggregates in various tissues.

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  • Analysis of Prnp gene polymorphisms in affected cervid populations.

    • Main Results:

    • CWD has been detected in 12 additional US states and 2 Canadian provinces.
    • Extensive PrP(Sc) aggregates are found in the central nervous system and peripheral tissues of infected deer and elk.
    • Specific Prnp gene polymorphisms (codon 225 in deer, codon 132 in elk) are associated with CWD susceptibility.

    Conclusions:

    • CWD is spreading geographically, posing a significant challenge for wildlife management.
    • The presence of PrP(Sc) in peripheral tissues may facilitate prion shedding and transmission.
    • Genetic factors influence susceptibility, complicating control efforts for this wildlife prion disease.