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Treatment of hereditary angioneurotic oedema (HANE) with tibolone
H W Ott1, V Mattle, D Hadziomerovic
1Clinical Division of Gynaecological Endocrinology and Reproductive Medicine, Medical University of Innsbruck, Austria. helmut.ott@uibk.ac.at
Objective:
Eight women, aged 25-58 years, with hereditary angioneurotic oedema (HANE) were treated with tibolone, a synthetic steroid exhibiting oestrogenic, androgenic and progestational activity.
Design:
Pilot study.
Results:
Tibolone at a dose of 2.5-7.5 mg/day significantly reduced the number and severity of attacks and the number of ampoules of C1-esterase inhibitor (C1-INH) needed for symptomatic therapy. The efficacy of tibolone was comparable to that of danazol, while the androgenic side-effects were considerably reduced.
Conclusions:
Tibolone may represent an alternative to danazol administration for the prophylaxis of HANE in women.
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