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Related Experiment Videos

Microglia activation in sepsis: a case-control study.

Afina W Lemstra1, Jacqueline C M Groen in't Woud, Jeroen J M Hoozemans

  • 1Department of Neurology, Academic Medical Centre, Amsterdam, The Netherlands. a.w.lemstra@amc.uva.nl

Journal of Neuroinflammation
|January 17, 2007
PubMed
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Sepsis infection activates brain microglia in deceased patients, suggesting a role in sickness behavior. This study confirms microglial activation in human sepsis brains, linking infection to neurological changes.

Area of Science:

  • Neuroscience
  • Immunology
  • Pathology

Background:

  • Infections trigger the acute phase response and sickness behavior.
  • Microglial cells are implicated in mediating behavioral changes during systemic infections.
  • Animal models show microglial activation in the brain following lipopolysaccharide (LPS) induction in sepsis.

Purpose of the Study:

  • To investigate microglial activation in the brains of patients who died from sepsis.
  • To determine if observed microglial activation in animal models translates to human sepsis cases.

Main Methods:

  • A case-control study comparing brain tissue from 13 sepsis patients and 17 controls.
  • Identification of activated microglia via MHC-class II antigens and CD68 expression.
  • Semiquantitative scoring of microglia activation based on cell number and morphology.

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Main Results:

  • Significant increase in CD68-positive activated microglia in the grey matter of sepsis patients compared to controls.
  • Microglial activation was observed independently of the patients' age.
  • Demonstrated a clear link between sepsis and microglial activation in human brain tissue.

Conclusions:

  • First evidence of microglial activation in human brain tissue associated with systemic sepsis.
  • Activated microglia in sepsis may contribute to the associated behavioral changes.
  • Highlights the brain's involvement in the systemic response to infection.