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Updated: Jul 17, 2026

Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model
Published on: March 5, 2022
Is the polycystic ovary syndrome associated with chronic inflammation per se?
Magdalena Olszanecka-Glinianowicz1, Michał Banaś, Barbara Zahorska-Markiewicz
1Department of Pathophysiology, Silesian University School of Medicine, Medyków Street 18, 40-752 Katowice, Poland. magols@esculap.pl
Objective:
The aim of the present study was to evaluate serum concentrations of tumor necrosis factor-alpha (TNF-alpha), TNF-soluble receptors, and IL-6 in obese women without additional diseases and obese women with polycystic ovary syndrome (PCOS).
Study Design:
The study group consisted of 39 obese women with PCOS and 34 age-matched obese women without additional disease were included as controls. Blood glucose, total cholesterol, HDL-cholesterol, and triglycerides were measured by the enzymatic procedure. Plasma insulin, follicle-stimulating hormone (FSH), luteinizing hormone (LH), dehydroepiandrosterone sulfate (DHEAS), androstenedione, total and free testosterone, cortisol, progesterone, 17OH-progesterone, estradiol, and sex hormone binding globulin (SHBG) were measured by a commercial radioimmunoassay (RIA). Tumor necrosis factor-alpha (TNF-alpha), soluble TNF receptors (sTNFRs), and IL-6 were determined by an ELISA.
Results:
We did not observe any differences in serum concentrations of TNF-alpha between obese women with and without PCOS. Serum concentrations of sTNFR1 and sTNFR2 were significantly higher in PCOS patients compared with controls; however, serum concentrations of IL-6 were significantly lower in PCOS patients.
Conclusions:
Our findings suggest that PCOS is not associated with chronic inflammation.
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