Related Experiment Video

Updated: Jul 17, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Regression of dilated-hypokinetic hypertrophic cardiomyopathy by biventricular cardiac pacing

Houman Ashrafian1, Mark J Mason, Andrew G Mitchell

  • 1Department of Cardiology, The Royal Brompton and Harefield NHS Trust, Harefield Hospital, Middlesex UB9 6JH, UK. ashrafian@hotmail.com

Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology
|January 17, 2007
PubMed

Insights

Dilated hypertrophic cardiomyopathy (HCM) can reverse with biventricular pacing and cardiac resynchronization therapy (CRT). This case suggests CRT may offer a new treatment for advanced HCM, challenging its

Area of Science:

  • Cardiology
  • Cardiac Electrophysiology

Background:

  • Dilated and hypokinetic hypertrophic cardiomyopathy (HCM) is an advanced, often irreversible, stage associated with poor prognosis.
  • Adverse outcomes include sudden cardiac death, necessitating defibrillator implantation or cardiac transplantation.

Observation:

  • A case demonstrating significant regression of the dilated-hypokinetic state in HCM is presented.
  • The intervention utilized was biventricular pacing, a form of cardiac resynchronization therapy (CRT).

Findings:

  • Cardiac resynchronization therapy (CRT) induced profound regression in a patient with end-stage hypertrophic cardiomyopathy.
  • This challenges the established view of the 'burnt-out' phase of HCM as irreversible.

Implications:

  • Cardiac resynchronization therapy (CRT) may represent a viable therapeutic option for specific hypertrophic cardiomyopathy variants.
  • Further systematic research is crucial to validate the role and efficacy of CRT in managing advanced HCM.

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