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Acellular dermal matrix grafts for prevention of microarterial thrombophlebitis
Jivianne T Lee1, Sunita Bhuta, Thomas C Calcaterra
1Division of Head and Neck Surgery, Department of Surgery, David Geffen School of Medicine, University of California, Los Angeles, USA.
Objective:
To examine the role of acellular dermal matrix grafts for prevention of microarterial anastomotic thrombophlebitis.
Design:
Bilateral femoral artery microvascular anastomoses were created in the field of established wounds infected with Staphylococcus aureus in 12 rats. In each animal, 1 femoral microarterial anastomosis was wrapped with an acellular dermal matrix graft, and the contralateral femoral anastomosis was left unprotected. The incidence of femoral artery thrombosis was determined after 4 days by wound reexploration.
Setting:
David Geffen School of Medicine, University of California, Los Angeles.
Main Outcome Measure:
The patency of femoral artery anastomoses was determined after 4 days by wound reexploration.
Results:
The incidence of femoral artery thrombosis in vessels wrapped with acellular dermal matrix grafts was 17%. The incidence of femoral artery thrombosis in unprotected vessels was 100%. This difference was statistically significant (P<.05).
Conclusion:
Acellular dermal matrix grafts seem to have a protective effect in the prevention of acute thrombophlebitis when arterial microvascular anastomoses are performed in infected surgical fields.
