Related Experiment Video
Updated: Jul 17, 2026
05:21
A Luciferase-fluorescent Reporter Influenza Virus for Live Imaging and Quantification of Viral Infection
Published on: August 14, 2019
Influenza vaccines: a pediatric perspective.
1Pediatric Infectious Disease, Tufts-New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA. cmeissner@tufts-nemc.org
Current Opinion in Pediatrics
|January 17, 2007
Summary
Annual influenza immunization is recommended for children aged 6-59 months and their contacts. This strategy, including a two-dose plan for younger children, aims to reduce disease burden and mortality.
Area of Science:
- Pediatrics
- Infectious Diseases
- Immunology
Background:
- Influenza poses a significant disease burden on children.
- Current immunization recommendations for young children are evolving.
Purpose of the Study:
- To review the disease burden of influenza in children.
- To understand the rationale behind updated immunization recommendations for young children.
- To examine current recommendations for trivalent, inactivated influenza vaccine and live, attenuated influenza vaccine.
Main Methods:
- Review of current scientific literature and public health recommendations regarding influenza vaccination in children.
Main Results:
- Annual influenza immunization is recommended for all children aged 6 to 59 months and their household contacts, starting from the 2006-2007 season.
- A two-dose vaccination strategy is advised for children under 9 years of age.
Conclusions:
- Expanded influenza immunization recommendations are anticipated to decrease outpatient visits, hospitalizations, and mortality rates associated with influenza in both pediatric and adult populations.
Related Concept Videos
01:27Influenza
Influenza is an acute, highly communicable viral disease that affects the respiratory tract and is responsible for seasonal epidemics worldwide. Influenza A is the most prevalent type associated with widespread outbreaks and is subtyped based on two surface glycoproteins: hemagglutinin (H) and neuraminidase (N), as in H1N1. These glycoproteins are essential for viral infectivity, transmission, and immune recognition. Transmission occurs primarily through respiratory droplets and contaminated...
01:51Vaccinations
Overview
01:29Respiratory Syncytial Virus Disease
Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
01:23Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption
Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
01:26Pharmacokinetics in Pediatric Patients: Drug Excretion
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
01:29Drug Dosing: Infants and Children
Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...