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Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale

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Skin barrier function in atopic dermatitis.

Brian P Vickery¹

¹Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA. brain.vickery@yale.edu

Current Opinion in Pediatrics

|January 17, 2007

Summary

This summary is machine-generated.

Genetic defects in skin barrier function are major risk factors for atopic dermatitis and asthma. Impaired skin barrier may lead to allergic sensitization, shifting focus from adaptive immunity to barrier dysfunction.

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Isolation and Culture of Primary Mouse Keratinocytes from Neonatal and Adult Mouse Skin

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Published on: July 14, 2017

Area of Science:

Dermatology
Immunology
Genetics

Background:

Atopic dermatitis research has primarily focused on adaptive immune responses.
Emerging evidence suggests skin barrier impairment may precede allergic sensitization.

Purpose of the Study:

To highlight the role of skin barrier dysfunction in the development of atopic dermatitis.
To emphasize genetic factors contributing to skin barrier defects.

Main Methods:

Review of current research on atopic dermatitis pathogenesis.
Analysis of genetic associations with filaggrin (FLG) mutations.

Main Results:

Two common FLG gene mutations, leading to filaggrin deficiency, are strongly linked to atopic dermatitis.
These mutations are also associated with asthma in individuals with atopic dermatitis.

Conclusions:

Genetic defects in skin barrier function are significant risk factors for atopic dermatitis.
Understanding these genetic defects is crucial for managing and preventing atopic dermatitis and associated asthma.