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Updated: Aug 9, 2026

Techniques to Induce and Quantify Cellular Senescence
Published on: May 1, 2017
Genes for insulin-like growth factors I and II are expressed in senescent rat tissues
1Department of Physiology and Biophysics, University of Illinois, Urbana.
Abstract:
Insulin-like growth factor IGF-I and IGF-II gene expression was measured for the first time in rat liver, brain and heart during the later stages of life, i.e., young adulthood (6 months) to senescence (25 months). IGF-I mRNA was detected in all three tissues at all ages. Its relative level decreased the most in the liver with advancing age. IGF-II mRNA was detected in the brain and heart but not the liver at all ages. The level of IGF-II mRNA decreased only slightly in the brain from young adulthood to senescence.
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