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Therapeutic goals for effective platelet inhibition: a consensus document

Stephen D Wiviott1, Alan D Michelson, Peter B Berger

  • 1Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Reviews in Cardiovascular Medicine
|January 17, 2007
PubMed

Insights

Clopidogrel and aspirin are standard antiplatelet treatments, but new P2Y12 antagonists show promise. These novel agents may overcome clopidogrel

Area of Science:

  • Cardiology
  • Pharmacology
  • Thrombosis

Background:

  • Clopidogrel combined with aspirin is a primary antiplatelet therapy for acute coronary syndromes and after stent placement.
  • Limitations of clopidogrel include slow onset of action, variable patient response, bleeding risk, and prolonged recovery of platelet function.

Purpose of the Study:

  • To review novel P2Y12 receptor antagonists.
  • To explore agents that may overcome limitations of current clopidogrel therapy.

Main Methods:

  • Review of investigational P2Y12 receptor antagonists.
  • Focus on pharmacological properties and clinical development stages.

Main Results:

  • Several novel P2Y12 antagonists are in advanced clinical development.
  • These agents possess pharmacological properties potentially addressing clopidogrel's limitations.

Conclusions:

  • Investigational P2Y12 antagonists like prasugrel, AZD6140, and cangrelor show potential for improved antiplatelet therapy in coronary artery disease.
  • These novel agents may offer advantages over clopidogrel, addressing its therapeutic shortcomings.

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