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Tumor-induced osteomalacia.

Mala Kaul1, Miriam Silverberg, Edward F Dicarlo

  • 1Weill Medical College of Cornell University, New York, NY, USA.

Clinical Rheumatology
|January 17, 2007
PubMed
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Tumor-induced osteomalacia, a rare paraneoplastic syndrome, causes vitamin D resistant osteomalacia due to a tumor. This case report highlights the diagnostic challenges of oncogenic osteomalacia, often overlooked in rheumatology.

Area of Science:

  • Endocrinology
  • Oncology
  • Rheumatology

Background:

  • Tumor-induced osteomalacia (TIO), or oncogenic osteomalacia, is a rare paraneoplastic syndrome.
  • It is characterized by vitamin D resistant osteomalacia caused by a tumor secreting phosphaturic substances.

Observation:

  • A case report details a young woman presenting with symptoms suggestive of osteomalacia.
  • She sought a rheumatologist's opinion, leading to the diagnosis of oncogenic osteomalacia.

Findings:

  • Oncogenic osteomalacia is infrequently discussed in rheumatology literature.
  • The diagnosis of this rare condition is often more challenging than its treatment.

Implications:

  • Highlights the importance of considering rare paraneoplastic syndromes in differential diagnoses.

Related Experiment Videos

  • Emphasizes the need for increased awareness and diagnostic strategies for oncogenic osteomalacia within rheumatology.
  • Suggests further research into diagnostic markers and treatment protocols for TIO.