[Acute ST-segment elevation also possible in non-coronary disorders]
G A J Jessurun1, F Zijlstra, H J Siebelink
1Universitair Medisch Centrum Groningen, Thoraxcentrum, afd. Cardiologie, Postbus 30.001, 9700 RB Groningen.
Insights
ST-segment elevation on ECG can mimic ST-elevation myocardial infarction (STEMI) but may stem from non-coronary conditions like pericarditis, pneumothorax complications, or sepsis. Careful clinical evaluation is crucial for accurate diagnosis and treatment.
Area of Science:
- Cardiology
- Emergency Medicine
- Diagnostic Imaging
Background:
- ST-segment elevation myocardial infarction (STEMI) is a critical diagnosis often managed with percutaneous coronary intervention.
- Electrocardiogram (ECG) changes are pivotal in diagnosing STEMI.
- Non-coronary conditions can present with ECG findings mimicking STEMI.
Observation:
- Three patients presented with symptoms suggestive of acute coronary syndrome and ECG findings of ST-segment elevation.
- Case 1: A young male diagnosed with pericarditis and myocarditis despite normal coronary arteries.
- Case 2: An elderly female with ST-segment elevation due to chest drain insertion for pneumothorax.
- Case 3: An ICU patient with ST-segment elevation attributed to sepsis and non-significant coronary artery disease.
Findings:
- ST-segment elevation on ECG is not exclusive to myocardial infarction.
- Non-coronary causes, including inflammatory conditions, mechanical pressures, and sepsis, can induce STEMI-like ECG changes.
- All three patients recovered with appropriate management for their underlying non-coronary conditions.
Implications:
- Clinicians must consider 'coronary mimicry' when interpreting ST-segment elevation on ECG.
- A thorough clinical assessment and correlation with patient presentation are essential to differentiate STEMI from non-coronary causes.
- Over-reliance on ECG findings without clinical context can lead to misdiagnosis and inappropriate treatment.
Abstract:
Three patients were referred with symptoms of acute coronary syndrome. The ECG results indicated ST-segment elevation. A 39-year-old man had normal coronary arteries and was eventually diagnosed with pericarditis and myocarditis. A 71-year-old woman had ST-segment elevation caused by mechanical pressure from a chest drain that was inserted for a pneumothorax. A 62-year-old man was admitted to the intensive care unit and was found to have ST-segment elevation related to sepsis and non-significant coronary artery disease. All 3 patients recovered following adequate treatment. Percutaneous coronary intervention is the first choice therapy for ST-segment elevation myocardial infarction (STEMI). However, ST-segment elevation can also occur in patients with non-coronary disorders. Clinicians should be encouraged to scrutinise 'STEMI' as a referral diagnosis and check if there are signs of coronary mimicry, i.e. ECG changes due to a non-coronary underlying cause. The ECG changes should be considered in relation to the clinical data at presentation, rather than interpreted as a single diagnostic finding.
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