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Bufadienolides from Urginea maritima sensu strictu
1Institut für Pharmakognosie der Universität Wien, Währingerstr.25, A-1090 Wien, Austria.
Planta Medica
|December 1, 1991
Summary
Fourteen bufadienolides, including four novel compounds, were identified in the bulbs of Urginea maritima. This research expands the known chemical diversity of bufadienolides from this plant species.
Area of Science:
- Phytochemistry
- Natural Product Chemistry
- Pharmacognosy
Background:
- Urginea maritima (L.) Baker sensu strictu is a plant known for its medicinal properties.
- Bufadienolides are a class of cardiac glycosides with significant pharmacological activities.
- Hexaploid varieties of Urginea maritima may possess unique chemical profiles.
Purpose of the Study:
- To isolate and identify bufadienolides from the bulbs of hexaploid Urginea maritima.
- To characterize novel bufadienolide compounds.
- To contribute to the understanding of the chemical constituents of Urginea maritima.
Main Methods:
- Bulb extraction and isolation of bufadienolides.
- Spectroscopic analysis including Fast Atom Bombardment Mass Spectrometry (FAB-MS).
- Nuclear Magnetic Resonance (NMR) spectroscopy: 1D-NMR and 13C-NMR.
- Comparison with authentic reference compounds.
Main Results:
- Fourteen bufadienolides were successfully isolated from the plant material.
- Ten known bufadienolides were identified: proscillaridin A, scillaren A, glucoscillaren A, scilliphaeoside, glucoscilliphaeoside, 12- EPI-scilliphaeoside, gamabufotalin-3- O-alpha- L-rhamnoside, 16beta- O-acetyl-gamabufotalin-3- O-alpha- L-rhamnoside, scilliglaucoside, and scillicyanoside.
- Four new bufadienolides were discovered: 5alpha-4,5-dihydroproscillaridin A, 5alpha-4,5-dihydroglucoscillaren A, gamabufotalin-3- O-alpha- L-rhamnosido-beta- D-glucoside, and 19-oxo-5alpha-4,5-dihydro-proscillaridin A.
Conclusions:
- The hexaploid Urginea maritima bulbs are a rich source of diverse bufadienolides.
- The identification of four new bufadienolides expands the chemical knowledge of this plant genus.
- Further research into the pharmacological properties of these isolated compounds is warranted.
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