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Updated: Jul 17, 2026

Mass Spectrometry and Luminogenic-based Approaches to Characterize Phase I Metabolic Competency of In Vitro Cell Cultures
Published on: March 28, 2017
The metabolism of a natural product: lessons learned from cyanogenic glycosides
1Department of Biochemistry and Biophysics, University of California, Davis, California 95616, U.S.A.
Abstract:
The biosynthesis, compartmentation, and catabolism of cyanogenic glycosides are discussed for the cases of some selected examples. These include amygdalin (occurring widely in the Rosaceae), the aliphatic cyanogens linamarin and lotaustralin (widely occurring, especially in the Leguminosae), and dhurrin together with its epimer taxiphyllin (occurring in the genus SORGHUM). Mechanistic studies including tracer experiments are described in detail. Unusual and even unique metabolites of amino acids have been identified as intermediates in these biosynthetic processes.
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