Related Experiment Video
Updated: Jul 17, 2026

Applications of Liquid-Chromatography Tandem Mass Spectrometry in Natural Products Research: Tropane Alkaloids as a Case Study
Published on: March 8, 2024
Endogenous Alkaloids in Man - Synthesis, Analytics, in vivo Identification, and Medicinal Importance*,1
G Bringmann1, D Feineis, H Friedrich
1Institute of Organic Chemistry, University of Würzburg, Am Hubland, D-8700 Würzburg, Federal Republic of Germany.
Abstract:
The IN VITRO and IN VIVO condensation of endogenous (or administered) reactive amines and carbonyl compounds is reported, leading to alkaloid-type heterocycles. The spectrum of the presented "mammalian alkaloids" ranges from isoquinoline derivatives, via beta-carbolines, through to thiazolidines, arising from vitamin B (6), chloral, and glyoxylic acid, respectively. Formation of these compounds may occur accidentally, but might also be induced intentionally, as a therapy for metabolic diseases.
More Related Videos
09:10An Efficient and Rapid HPLC-QQQ-MS Method for the Quantitation of Tropane Alkaloids in Medicinal Plants
Published on: June 12, 2026
11:44Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B
Published on: January 19, 2022
Related Concept Videos
Antidotes
Specific antidotes operate by inhibiting the enzymes that control biochemical pathways, reducing the production of harmful metabolites.
An example of an antidote is atropine, which counteracts the detrimental effects of cholinesterase inhibitors. It achieves this by deactivating muscarinic receptors,...
Amines: Introduction
Direct-Acting Cholinergic Agonists: Pharmacokinetics
Physical Properties of Amines
Analgesia and Pain Management
Drug Discovery: Overview