Related Experiment Video
Updated: Jul 17, 2026

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans
Published on: December 18, 2016
Neuropsychology of cortical versus subcortical dementia syndromes
David P Salmon1, J Vincent Filoteo
1Department of Neurosciences (0948), University of California, San Diego9500 Gilman Drive, La Jolla, CA 92093-0948, USA.
Abstract:
Neuropsychological studies have shown that there are several prominent differences in the patterns of cognitive deficits that occur in neurodegenerative disorders that have their primary etiology in either cortical or subcortical brain dysfunction. Quantitative and qualitative differences are apparent across many cognitive domains, including memory (in all its aspects), attention, executive functions, language and semantic knowledge, and visuospatial abilities. These distinct patterns of deficits have been broadly characterized as forming cortical and subcortical dementia syndromes. Differentiating between cortical and subcortical dementia provides a heuristically useful model for understanding brain-behavior relationships in neurodegenerative diseases and may improve the ability to clinically distinguish among various dementing disorders.
More Related Videos
Related Concept Videos
Dementia l: Introduction
Dementia
The progression of dementia is generally gradual.
Alzheimer Disease ll: Pathophysiology
Alzheimer's Disease: Overview
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
Alzheimer Disease l: Introduction
Role of Cerebellum and Prefrontal Cortex in Memory

