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Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
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Dementia with Lewy bodies.

David Weisman1, Ian McKeith

  • 1Department of Neurosciences and the Alzheimer's Disease Research Center, University of California, San Diego, CA 92093, USA.

Seminars in Neurology
|January 18, 2007
PubMed
Summary

Dementia with Lewy bodies (DLB) is a common neurodegenerative disease in the elderly, characterized by cognitive decline, visual hallucinations, and motor symptoms. Revised diagnostic criteria improve assessment of this progressive dementia.

Area of Science:

  • Neurology
  • Neuroscience
  • Geriatrics

Background:

  • Synucleinopathies, including dementia with Lewy bodies (DLB), are a group of progressive neurodegenerative disorders.
  • DLB is the second most common cause of dementia in the elderly, characterized by Lewy body pathology.
  • Neuropathology in DLB shows a broad distribution, often co-occurring with Alzheimer's disease pathology.

Purpose of the Study:

  • To present revised diagnostic criteria for DLB based on an international consortium.
  • To incorporate new information on core clinical features and assessment methods for DLB.
  • To provide an overview of the clinical presentation, diagnostic features, and management of DLB.

Main Methods:

  • Review of neuropathologic findings in DLB.

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  • Analysis of clinical features and diagnostic criteria from an international consortium.
  • Assessment of diagnostic support from neuroimaging and electroencephalogram.

    • Main Results:

    • Revised criteria for DLB diagnosis enhance clinical and pathological assessment.
    • DLB presents with cortical and subcortical cognitive impairments, notably visuospatial and executive dysfunction.
    • Core clinical features include fluctuating attention, visual hallucinations, and parkinsonism; suggestive features include REM sleep behavior disorder and neuroimaging findings.

    Conclusions:

    • DLB is a significant neurodegenerative dementia with distinct clinical and pathological features.
    • Revised diagnostic criteria facilitate more accurate identification and assessment of DLB.
    • Comprehensive management strategies are essential for addressing the multifaceted symptoms of DLB.