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Related Experiment Videos

Multiple sclerosis.

Ralph H B Benedict1, Julie H Bobholz

  • 1Department of Neurology, State University of New York (SUNY) at Buffalo, Jacobs Neurological Institute, Buffalo, New York, USA.

Seminars in Neurology
|January 18, 2007
PubMed
Summary
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Multiple sclerosis (MS) can cause cognitive impairment and dementia in 22% of patients. Neuropsychiatric symptoms in MS dementia correlate with brain atrophy, offering hope for new treatments.

Area of Science:

  • Neuroscience
  • Neurology

Background:

  • Multiple sclerosis (MS) is a central nervous system demyelinating disease.
  • It frequently causes inflammatory and atrophic brain pathology, leading to cognitive impairment.

Purpose of the Study:

  • To better understand the frequency, quality, and correlates of cognitive impairment in MS.
  • To investigate the relationship between neuropsychiatric manifestations of MS dementia and brain atrophy.

Main Methods:

  • Utilized standardized neuropsychological testing.
  • Employed quantitative brain imaging techniques, including magnetic resonance imaging (MRI).

Main Results:

  • Dementia occurs in 10-25% of MS patients; observed frequency was 22% in clinic attendees.

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  • Neuropsychiatric symptoms like personality changes and social empathy deficiency were noted.
  • These symptoms correlated with MRI indicators of brain atrophy (ventricle enlargement, neocortical volume, normalized whole brain volume).

    • Conclusions:

    • Cognitive impairment and dementia are significant concerns in MS.
    • Brain atrophy is a key correlate of neuropsychiatric manifestations in MS dementia.
    • Emerging treatments offer promise for managing degenerative aspects and cognitive symptoms in MS.