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Acitretin decreases tumor cell-induced angiogenesis
L Rudnicka1, M Marczak, A Szmurło
1Department of Dermatology, Warsaw School of Medicine, Poland.
Skin Pharmacology : the Official Journal of the Skin Pharmacology Society
|January 1, 1991
Summary
This study shows that retinoids like acitretin and etretinate can inhibit tumor-induced angiogenesis. Acitretin demonstrated broader efficacy against different cancer cell lines, suggesting a role in retinoid anticancer effects.
Area of Science:
- Oncology
- Dermatology
- Pharmacology
Background:
- Retinoids are vitamin A derivatives with known anticancer properties.
- Angiogenesis, the formation of new blood vessels, is crucial for tumor growth and metastasis.
Purpose of the Study:
- To evaluate the anti-angiogenic effects of acitretin and etretinate on keratinocyte-derived tumors in mice.
- To explore the potential mechanisms behind the anticancerogenic effects of retinoids.
Main Methods:
- Intradermal injection of keratinocyte tumor cell lines (A431, Pam 212, SKv) into Balb/c mice to induce angiogenesis.
- Administration of acitretin and etretinate to assess their inhibitory effects on blood vessel formation.
Main Results:
- Both acitretin and etretinate inhibited angiogenesis induced by the human epidermoid carcinoma cell line (A431).
- Acitretin, but not etretinate, inhibited angiogenesis induced by the murine keratinocyte cell line (Pam 212) and the HPV16-harboring SKv cell line.
Conclusions:
- Inhibition of angiogenesis is a potential mechanism for the anticancerogenic effects of retinoids.
- Acitretin exhibits a broader spectrum of anti-angiogenic activity compared to etretinate against tested keratinocyte tumor models.