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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
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Interstitial brachytherapy for childhood soft tissue sarcoma.

Siddhartha Laskar1, Gaurav Bahl, Mary Ann Muckaden

  • 1Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, India. laskars2000@yahoo.com

Pediatric Blood & Cancer
|January 18, 2007
PubMed
Summary

Interstitial brachytherapy (BRT) offers good local control for pediatric soft tissue sarcomas (STS). Judicious use of BRT alone can yield excellent outcomes with reduced morbidity in select pediatric STS patients.

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Area of Science:

  • Pediatric Oncology
  • Radiation Oncology
  • Surgical Oncology

Background:

  • Soft tissue sarcomas (STS) are rare in children.
  • Combined modality treatment is often used for pediatric STS.
  • Interstitial brachytherapy (BRT) is a potential loco-regional treatment option.

Purpose of the Study:

  • To evaluate the efficacy of interstitial brachytherapy (BRT) in children with soft tissue sarcomas (STS).
  • To assess the impact of BRT, alone or combined with external beam radiotherapy (EBRT), on treatment outcomes.
  • To identify factors influencing local control in pediatric STS treated with BRT.

Main Methods:

  • Retrospective analysis of 50 children with STS treated with interstitial BRT from 1984-2003.
  • Treatment included wide local excision and BRT, with or without EBRT.

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  • Analysis of local control (LC), disease-free survival, and overall survival based on tumor characteristics and treatment modalities.

    • Main Results:

    • Overall local control (LC) was 82% after a median follow-up of 51 months.
    • Factors associated with superior LC included smaller tumor size (
    • BRT combined with EBRT showed comparable LC to BRT alone; no significant difference in LC between LDR and HDR BRT was observed.

    Conclusions:

    • Interstitial BRT, with or without EBRT, provides satisfactory outcomes for pediatric STS.
    • Radical BRT alone, when carefully selected, achieves excellent local control and functional outcomes.
    • This approach can reduce treatment-related morbidity in pediatric STS patients.