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Updated: Jul 17, 2026
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Isolation and Expansion of Mesenchymal Stem/Stromal Cells Derived from Human Placenta Tissue
Published on: June 6, 2016
Placental mesenchymal dysplasia
Zahida Parveen1, Jane Elaine Tongson-Ignacio, Cory R Fraser
1University of Hawaii Pathology Residency Program, Honolulu, USA. zahipar@yahoo.com
Archives of Pathology & Laboratory Medicine
|January 18, 2007
Summary
Placental mesenchymal dysplasia, a condition causing an enlarged placenta, can mimic molar pregnancy. Early recognition of fetal complications is crucial to prevent unnecessary pregnancy termination.
Area of Science:
- Reproductive Medicine
- Pathology
- Genetics
Background:
- Placental mesenchymal dysplasia (PMD) presents with an enlarged placenta (placentomegaly).
- It can be misdiagnosed as molar pregnancy due to "grapelike vesicles."
- Associated fetal outcomes range from normal to growth restriction or Beckwith-Wiedemann syndrome features.
Purpose of the Study:
- To comprehensively review placental mesenchymal dysplasia.
- Key areas include etiology, molecular pathology, and clinical presentation.
- The review also covers diagnostic challenges and complications.
Main Methods:
- Systematic literature search of PubMed and Medline databases (1970-2006).
- Keywords included "placental mesenchymal dysplasia," "mesenchymal hyperplasia," "molar pregnancy," "pseudomolar pregnancy," "Beckwith-Wiedemann syndrome," and "placentomegaly."
- References from review articles were also examined.
Main Results:
- Placental mesenchymal dysplasia is characterized by abnormal placental villous stromal development.
- Ultrasonography may reveal a cystic placenta, necessitating differential diagnosis.
- Fetal morphology assessment is vital for identifying complications.
Conclusions:
- Consider placental mesenchymal dysplasia in cases of cystic placenta on ultrasound.
- Careful evaluation of fetal morphology aids in early detection of complications.
- Accurate diagnosis helps prevent unnecessary pregnancy termination, especially with normal fetuses.
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