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Related Concept Videos

Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure entails...
Esophageal Achalasia01:27

Esophageal Achalasia

Esophageal achalasia is a chronic neurogenic disorder characterized by impaired relaxation of the lower esophageal sphincter (LES) and absent or ineffective peristalsis in the distal esophagus. This leads to a functional obstruction without a physical blockage, despite significant disruption of esophageal motility.EtiologyAchalasia is caused by degeneration of the myenteric (Auerbach's) plexus, specifically the loss of inhibitory ganglion cells that produce vasoactive intestinal peptide (VIP)...
Barrett Esophagus-I: Introduction01:21

Barrett Esophagus-I: Introduction

Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more similar...
Gastroesophageal Reflux Disease01:25

Gastroesophageal Reflux Disease

Gastroesophageal reflux disease (GERD) is the backward flow of stomach contents (acid, pepsin, or bile) into the esophagus, causing mucosal inflammation known as esophagitis. It results from failure of antireflux mechanisms, mainly the lower esophageal sphincter (LES), influenced by mechanical and physiological factors.Etiology and Risk FactorsGERD develops when LES function is weakened or when intra-abdominal pressure increases. Risk factors include aging, obesity, and sliding hiatal hernia,...
Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Esophageal Strictures-II: Clinical Features and Management01:26

Esophageal Strictures-II: Clinical Features and Management

Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...

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Related Experiment Video

Updated: Jul 17, 2026

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
03:23

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis

Published on: May 10, 2024

Eosinophilic esophagitis: an update.

D D Ferguson1, A E Foxx-Orenstein

  • 1Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota 55905, USA.

Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus
|January 18, 2007
PubMed
Summary

Eosinophilic esophagitis (EE) is a growing condition causing feeding issues and difficulty swallowing. Treatment with topical corticosteroids is common, but relapses frequently occur, and long-term outcomes remain unclear.

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Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation

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Last Updated: Jul 17, 2026

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
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Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation
10:15

Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation

Published on: March 22, 2017

Area of Science:

  • Gastroenterology
  • Immunology
  • Pediatrics

Background:

  • Eosinophilic esophagitis (EE) is an increasingly recognized immune-mediated esophageal disease.
  • It presents with distinct symptoms in children (feeding disorders, vomiting, abdominal pain) and adults (dysphagia, food impaction).
  • Histological confirmation requires over 20 eosinophils per high-powered field in esophageal biopsies.

Purpose of the Study:

  • To summarize the current understanding of eosinophilic esophagitis.
  • To highlight diagnostic criteria and common treatment approaches.
  • To address the frequency of symptomatic relapse and the unknown long-term prognosis.

Main Methods:

  • Review of current medical literature on eosinophilic esophagitis.
  • Analysis of diagnostic criteria based on esophageal histology.
  • Evaluation of treatment strategies, primarily topical corticosteroids.
  • Assessment of reported relapse rates and long-term outcome data.

Main Results:

  • EE diagnosis relies on specific esophageal eosinophil counts (>20/HPF).
  • Topical corticosteroids are the primary treatment for both pediatric and adult EE.
  • Symptomatic relapse after initial treatment is frequent, necessitating repeated interventions.
  • Long-term prognosis and disease progression data are currently limited.

Conclusions:

  • Eosinophilic esophagitis is a prevalent condition requiring ongoing management.
  • Current treatments, while effective short-term, are associated with high relapse rates.
  • Further research is crucial to understand the long-term prognosis and optimize management strategies for EE.