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Updated: Jul 17, 2026

Tracking Tumor Cell Dissemination from Lung Metastases Using Photoconversion

Tracking Tumor Cell Dissemination from Lung Metastases Using Photoconversion

Published on: July 7, 2023

Factors causing early relapse after lung metastasis surgery.

A Ríos¹, P J Galindo, J Torres

¹Departamento de Cirugía, Servicio de Cirugía Torácica, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain. arzrios@teleline.es

European Journal of Cancer Care

|January 18, 2007

Summary

Lung metastasectomy offers a viable treatment option for selected patients, with low morbidity and mortality. Key factors influencing outcomes include complete surgical resection, tumor type, disease-free interval, and metastasis count.

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Last Updated: Jul 17, 2026

Tracking Tumor Cell Dissemination from Lung Metastases Using Photoconversion

Tracking Tumor Cell Dissemination from Lung Metastases Using Photoconversion

Published on: July 7, 2023

Area of Science:

Oncology
Thoracic Surgery
Cancer Metastasis

Background:

The lungs act as a primary filter for distant tumor spread in most cancers.
In select cases, the metastatic process can be arrested in the lungs, making lung metastasectomy a potential therapeutic option.
Previous studies have indicated benefits of metastasectomy in carefully selected patients.

Purpose of the Study:

To analyze the morbidity and mortality associated with lung metastasectomy.
To identify factors that predict early relapse after lung metastasectomy.

Main Methods:

Retrospective analysis of 38 patients who underwent lung metastasectomy via posterolateral thoracotomy.
Variables analyzed included patient demographics, primary tumor characteristics, disease-free interval, metastasis details, surgical outcomes, and follow-up data.

Main Results:

No perioperative deaths were recorded. Morbidity was 11%, with one case requiring reintervention for haemothorax.
One, two, and three-year survival rates were 87%, 61%, and 25%, respectively.
Relapse-free rates at one, two, and three years were 71%, 56%, and 17%, respectively. Early relapse was associated with sarcoma histology, shorter disease-free intervals, and a higher number of metastases.

Conclusions:

Lung metastasectomy can be performed with acceptable morbidity and mortality rates.
Complete surgical resection, histological tumor type, disease-free interval, and the number of lung metastases are crucial prognostic factors for survival.