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Related Concept Videos

Burn Injuries

Burn Injuries

Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...

Healing II: Complications

Healing II: Complications

Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...

Clinical Applications of Epidermal Stem Cells

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...

Phases of Wound Repair

Phases of Wound Repair

Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...

Healing I: Introduction

Healing I: Introduction

Healing is the physiological process by which the body restores the integrity and function of damaged tissues following injury. It involves a coordinated interplay of cellular proliferation, extracellular matrix remodeling, and growth factor signaling. The extent and nature of the tissue damage determine whether healing occurs by resolution, regeneration, or replacement.ResolutionResolution represents the most complete form of healing, occurring when the injury is minimal and tissue...

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the exudate's...

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Related Experiment Video

Updated: Jul 17, 2026

Quantification of Strain in a Porcine Model of Skin Expansion Using Multi-View Stereo and Isogeometric Kinematics

Quantification of Strain in a Porcine Model of Skin Expansion Using Multi-View Stereo and Isogeometric Kinematics

Published on: April 16, 2017

Tissue expansion in burn sequelae repair.

João Medeiros Tavares Filho¹, Manoel Belerique, Diogo Franco

¹Clementino Fraga Filho University Hospital of Rio de Janeiro, Hospital Santa Teresa and Beneficência Portuguesa of Petrópolis, Brazil. jmedeiro@compuland.com.br

Burns : Journal of the International Society for Burn Injuries

|January 18, 2007

Summary

Tissue expanders offer an effective solution for treating burn scars, providing similar local skin characteristics without donor site injury. This method is repeatable for significant burn sequelae, proving beneficial in reconstructive surgery.

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A Swine Burn Model for Investigating the Healing Process in Multiple Depth Burn Wounds

A Swine Burn Model for Investigating the Healing Process in Multiple Depth Burn Wounds

Published on: February 23, 2024

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Last Updated: Jul 17, 2026

Quantification of Strain in a Porcine Model of Skin Expansion Using Multi-View Stereo and Isogeometric Kinematics

Quantification of Strain in a Porcine Model of Skin Expansion Using Multi-View Stereo and Isogeometric Kinematics

Published on: April 16, 2017

A Swine Burn Model for Investigating the Healing Process in Multiple Depth Burn Wounds

A Swine Burn Model for Investigating the Healing Process in Multiple Depth Burn Wounds

Published on: February 23, 2024

Area of Science:

Reconstructive Surgery
Dermatology
Plastic Surgery

Background:

Burn sequelae often result in challenging emotional, aesthetic, and functional deficits.
Traditional treatments like skin grafts can cause secondary donor site morbidity.
Tissue expansion presents a promising alternative for managing extensive burn sequelae.

Purpose of the Study:

To evaluate the efficacy and outcomes of tissue expander use in treating burn sequelae.
To assess complication rates and patient suitability for the procedure.

Main Methods:

A retrospective analysis of 54 cases (23 patients) with burn sequelae treated using tissue expanders.
Expanders were inserted in various anatomical planes (subgaleal, submuscular, subfascial, subcutaneous).
Surgical reconstruction involved advancement flaps (44 cases) and transposition flaps (6 cases).

Main Results:

Successful skin expansion was achieved in 92.5% of cases (50 out of 54).
A complication rate of 24.07% was observed, with most being relative complications.
The procedure demonstrated versatility across different anatomical locations.

Conclusions:

Tissue expansion is a valuable technique for burn sequelae reconstruction, yielding skin with native characteristics.
It avoids donor site morbidity associated with skin grafting.
The possibility of re-expansion makes it suitable for extensive or recurrent burn sequelae.