Related Experiment Video
Updated: Jul 17, 2026

Germ Cell Transplantation and Testis Tissue Xenografting in Mice
Published on: February 6, 2012
Management of recurrent testicular germ cell tumors
Guru Sonpavde1, Thomas E Hutson, Bruce J Roth
1US Oncology Research, Houston, Texas, USA. guru.sonpavde@usoncology.com
Abstract:
Although front-line chemotherapy cures most men with testicular germ cell tumors, salvage therapy is still important in a small but significant minority. Second-line conventional-dose or high-dose chemotherapy with stem cell rescue may cure 25%-50% of patients. New chemotherapeutic agents, including the taxanes gemcitabine and oxaliplatin, have added to the therapeutic armamentarium. Salvage surgical resection has an important role in selected patients. Cisplatin-refractory patients have a poor prognosis with current therapy, and novel chemotherapeutic and biologic agents need to be discovered for such patients.
Related Concept Videos
Disorders of the Male Reproductive System
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...
Treatment Resistent Cancers
Testes: Histology
The spermatogenic cells, responsible for producing sperm, are...
Treatment Resistant Cancers
