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Changes in the Appendicular Skeleton with Age

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Related Experiment Video

Updated: Jul 17, 2026

Skeletal Muscle Gender Dimorphism from Proteomics
09:29

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Published on: December 14, 2011

Age-dependent changes in bovine skeletal muscle transcriptomic profile.

T Sadkowski1, M Jank, J Oprzadek

  • 1Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw Agricultural University, Poland.

Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society
|January 18, 2007
PubMed
Summary

This study identified 53 genes influencing bovine skeletal muscle growth between 6 and 12 months. Key genes involved in muscle development and metabolism were pinpointed, offering insights into cattle growth.

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Area of Science:

  • Animal Science
  • Genomics
  • Molecular Biology

Background:

  • Postnatal muscle growth in bulls, primarily through hypertrophy, peaks between 180 and 360 days.
  • Key genes regulating skeletal muscle quantitative and qualitative changes during this critical growth phase remain largely unidentified.

Purpose of the Study:

  • To compare the transcriptomic profile of skeletal muscle (m. semitendinosus) in Polish Black and White bulls from 6 to 12 months of age.
  • To identify genes associated with age-dependent changes in bovine skeletal muscle during rapid growth.

Main Methods:

  • Utilized a bovine cDNA microarray (NBFGC EST collection) with 18,263 unique genes.
  • Analyzed gene expression changes in the m. semitendinosus of 12 bulls aged 6 and 12 months.

Main Results:

  • Identified 53 genes with consistent age-dependent expression changes across all animals.
  • Thirty-two of these genes exhibited at least a 2-fold difference in expression.
  • Highlighted genes with significant age-dependent up-regulation (e.g., MAD2L1 binding protein) and down-regulation (e.g., ubiquitin carboxy-terminal hydrolase L1, PECAM1).

Conclusions:

  • The identified genes likely play a role in the growth, development, and metabolic alterations of bovine skeletal muscle.
  • These findings provide a foundation for understanding the genetic mechanisms governing muscle development in cattle.