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The changes in angiogenic gene expression in recurrent multiple chorioangiomas
Denis Gallot1, Geoffroy Marceau, Hélène Laurichesse-Delmas
1CHU Clermont-Ferrand, Foetal Maternal Medicine Unit, Federation of Gynaecology and Obstetrics, Maternité Hôtel-Dieu, Clermont-Ferrand, France. dgallot@chu-clermontferrand.fr
Objectives:
To assess the messenger ribonucleic acid expression in placental tissue of growth factors, cytokines, angiogenic and anti-angiogenic factors in one case of recurrent multiple chorioangiomas.
Methods:
Complementary deoxyribonucleic acid array analysis was performed on the affected placentae and on normal placentaes (controls) to compare messenger ribonucleic acid levels of 96 genes involved in angiogenesis.
Results:
Eleven genes presented more than two-fold alteration in expression levels: undetectable (angiopoietin 1, osteonectin, tyrosine kinase endothelial, neuropilin 1), decreased (transcription growth factor beta receptor 3, tissue inhibitor of metalloproteinase type 2, EGF receptor, integrin-alpha V, tyrosine kinase vascular endothelial growth factor receptor 2), increased (angiopoietin 2, osteopontin).
Conclusions:
We illustrated the complexity of angiogenic disruption in recurrent multiple chorioangiomas leading to the difficulty to propose a single candidate gene to explain this pathology.
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