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Maternal morbidity following routine second trimester genetic amniocentesis
Y Erez1, A Ben-Shushan, U Elchalal
1Department of Obstetrics and Gynecology, Hadassah Medical Center, Ein-Kerem, Jerusalem. erezyair@gmail.com
Fetal Diagnosis and Therapy
|January 18, 2007
Summary
Routine second trimester amniocentesis can lead to serious septic complications, including sepsis and septic abortion. Prompt medical intervention is critical for managing these rare but severe cases.
Area of Science:
- Obstetrics and Gynecology
- Maternal-Fetal Medicine
- Infectious Diseases
Background:
- Amniocentesis is a common prenatal diagnostic procedure performed during the second trimester.
- While generally safe, potential complications, including infection, must be considered.
- This report details two instances of severe septic complications following amniocentesis.
Observation:
- Case 1: A 37-year-old gravida with ulcerative colitis underwent transabdominal amniocentesis at 18 weeks gestation.
- Despite sterile technique and ultrasound guidance, she developed septic abortion and sepsis within 28 hours.
- Case 2: A 34-year-old gravida developed amnionitis 10 hours post-amniocentesis at 24 weeks gestation, leading to septic abortion.
Findings:
- Both cases illustrate rare but severe septic complications following routine second-trimester amniocentesis.
- Infection can rapidly progress to sepsis and septic abortion, even after seemingly uncomplicated procedures.
- Underlying maternal conditions, such as ulcerative colitis, may potentially influence risk.
Implications:
- A high index of suspicion for infection is crucial in patients undergoing or post-amniocentesis.
- Rapid diagnosis and aggressive management, including antibiotics and supportive care, are vital for patient survival.
- These cases highlight the importance of meticulous sterile technique and patient monitoring after amniocentesis.
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