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[Carbohydrate metabolism enzymes in children with extrahepatic portal hypertension]

I V Chibisov, A F Leont'ev, V M Seniakovich

    Laboratornoe Delo
    |January 1, 1991
    PubMed

    Insights

    Extrahepatic portal hypertension in children significantly reduces liver glycogen and glucose-6-phosphatase activity, impacting blood glucose homeostasis. These biochemical changes impair the body's adaptive capacity, crucial for therapeutic planning.

    Area of Science:

    • Biochemistry
    • Pediatric Gastroenterology
    • Hepatology

    Context:

    • Extrahepatic portal hypertension (EHPHT) is a condition affecting children, leading to impaired liver function.
    • Understanding the biochemical alterations in the liver is crucial for managing EHPHT.
    • Previous research has not fully elucidated the specific enzymatic changes in pediatric EHPHT.

    Purpose:

    • To investigate glycogen and protein concentrations and the activities of key liver glycogen metabolic enzymes in children with EHPHT.
    • To identify characteristic biochemical markers associated with EHPHT in pediatric patients.
    • To explore correlations between enzyme activities, glycogen levels, and clinical outcomes.

    Summary:

    • This study analyzed liver glycogen metabolic enzymes in 22 children (4-15 years) with EHPHT.
    • Key findings include reduced phosphorylase alpha activity, decreased glycogen concentration, and diminished glucose-6-phosphatase activity.
    • Strong correlations were observed between these enzymatic changes and EHPHT, particularly involving phosphorylase alpha and glucose-6-phosphatase.

    Impact:

    • Impaired liver blood flow in EHPHT injures glucose homeostasis maintenance, a primary liver function.
    • Reduced blood glucose regulation diminishes the body's adaptive potential in affected children.
    • These findings highlight the importance of considering these biochemical deficits in therapeutic strategies for pediatric EHPHT.

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