Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Heart Failure V: Medical Management

Heart Failure V: Medical Management

Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...

Inhaled Medications

Inhaled Medications

Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...

Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure

Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure

Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue, improving...

Factors Affecting Respiration

Factors Affecting Respiration

Respiration is a crucial physiological function involving exchanging oxygen (O2) and carbon dioxide (CO2) between an organism and its environment. Various factors can impact this essential process:

Antiasthma Drugs: Methylxanthines

Antiasthma Drugs: Methylxanthines

Theophylline, a member of the methylxanthine class of bronchodilators, has long been used in asthma management. While its exact mechanism of action is not fully understood, it is believed to have multiple effects on various cellular processes.
Theophylline is thought to inhibit phosphodiesterase enzymes, increasing intracellular levels of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). This rise in cAMP and cGMP concentrations stimulates cardiac function,...

COPD: Management Using Bronchodilators and Corticosteroids

COPD: Management Using Bronchodilators and Corticosteroids

Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Acetazolamide reduces exercise capacity following a 5-day ascent to 4559 m in a randomised study.

BMJ open sport & exercise medicine·2018

Same author

High-intensity intermittent exercise increases pulmonary interstitial edema at altitude but not at simulated altitude.

Wilderness & environmental medicine·2014

Same author

Exercise limitation of acetazolamide at altitude (3459 m).

Wilderness & environmental medicine·2014

Same author

Time course variations in the mechanisms by which cerebral oxygen delivery is maintained on exposure to hypoxia/altitude.

High altitude medicine & biology·2014

Same author

Do changes in gastro-intestinal blood flow explain high-altitude anorexia?

European journal of clinical investigation·2010

Same author

Intrapulmonary and intracardiac shunting with exercise at altitude.

Wilderness & environmental medicine·2008

Search research articles

Related Experiment Videos

Medicine at high altitude.

Alex D Wright¹,

¹University of Birmingham. a.wright@bmres.org.uk

Clinical Medicine (London, England)

|January 19, 2007

Summary

High altitude medicine reveals hypoxia effects. Acute mountain sickness (AMS), triggered by rapid ascent and exercise, can be prevented with gradual acclimatization and medication, but severe cases may need medical intervention.

Area of Science:

High altitude physiology
Environmental medicine
Hypoxia research

Background:

High altitude medicine offers insights into hypoxia's acute and chronic effects.
Acute mountain sickness (AMS) is common above 2,500m, linked to increased capillary permeability.
Exercise is a significant risk factor for AMS.

Purpose of the Study:

To summarize the pathophysiology, risk factors, and management of acute mountain sickness (AMS).
To discuss the importance of acclimatization and adaptation to high altitude.
To highlight chronic high-altitude diseases related to polycythemia and pulmonary hypertension.

Main Methods:

Review of existing literature on high-altitude medicine and AMS.
Identification of risk factors and preventative measures for AMS.

Related Experiment Videos

Discussion of treatment strategies for severe AMS and chronic high-altitude conditions.

Main Results:

AMS is caused by increased capillary permeability, exacerbated by rapid ascent and exercise.
Preventative measures include gradual ascent, avoiding exertion, and acetazolamide.
Severe AMS may necessitate oxygen, dexamethasone, or descent; it can progress to pulmonary or cerebral edema.

Conclusions:

AMS is usually self-limiting but requires monitoring for potential progression.
Acclimatization and adaptation are crucial for high-altitude residents and workers.
Chronic diseases at high altitude are often associated with polycythemia and pulmonary hypertension.