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Updated: Jul 17, 2026

Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma
Published on: April 20, 2018
[Second primary tumors in head and neck cancer]
C A Alvarez Marcos1, J L Llorente Pendás, V Franco Gutiérrez
1Servicio de Otorrinolaringología, Hospital Valle del Nalón, Riaño-Langreo. alvarezmarcos@telefonica.net
Introduction:
The development of second primary tumors (SPT) in patients with head and neck squamous cell carcinoma (HNSCC) has become an increasingly important factor in clinical treatment decisions.
Purpose:
To define favourable clinical characteristics for overall survival, in patients with SP head and neck cancer.
Material And Method:
Records of 633 patients with SCC treated from 1984 to 2004 were reviewed to describe clinical characteristics of the SPT.
Results:
The overall incidence of SPT was 11%. The incidence of the index tumors was as follows: supraglottic cancer 21% and oral cancer 16%. The most common SPT occurred in head and neck area in 47%, lung in 32% and esophagus in 11%. Second primary was associated with a poor 5 years survival in patients with HN-SCC (23 versus 53% in control group).
Conclusion:
Because of the high rate of second primary tumors, protocols including chemoprophylaxis should be investigated. Prevention and early detection are indicated.
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