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Updated: Jul 17, 2026
09:31
Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
Published on: March 7, 2019
[Multifocal localized amyloidosis in a pediatric patient]
N Mesuro Domínguez1, J L Lacosta Nicolás
1Complejo Hospitalario San Millán- San Pedro, Logroño, La Rioja.
Acta Otorrinolaringologica Espanola
|January 19, 2007
Summary
Pediatric upper airway amyloidosis is uncommon. This case highlights primary amyloidosis in a 14-year-old girl
Area of Science:
- Otorhinolaryngology
- Pediatric Pathology
Background:
- Amyloidosis, a rare condition, typically affects older adults.
- Upper airway involvement in pediatric amyloidosis is exceptionally rare.
Observation:
- A 14-year-old female presented with symptoms of nasal obstruction and mucoid discharge.
- The patient had primary amyloidosis affecting the nasopharynx and nasal cavity.
Findings:
- Histological analysis of tissue obtained from local surgical excision confirmed the diagnosis.
- This confirmed primary amyloidosis in the pediatric nasopharynx and nasal cavity.
Implications:
- This case expands the understanding of rare pediatric upper airway diseases.
- Highlights the importance of considering amyloidosis in pediatric patients with persistent nasal symptoms.
- Emphasizes the role of histopathological examination for accurate diagnosis.
Related Concept Videos
03:03Amyloid Fibrils
Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...
03:03Amyloid Fibrils
Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...