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Published on: January 28, 2020

Relationship between platelet indexes and coronary angiographic findings in patients with ischemic heart disease

Akihiro Ihara1, Toshiharu Kawamoto, Kengo Matsumoto

  • 1Department of Hematology, National Hospital Organization Kure Medical Center, Hiroshima, Japan. a-ihara@kure-nh.go.jp

Pathophysiology of Haemostasis and Thrombosis
|January 19, 2007
PubMed

Insights

Platelet indexes like platelet-large cell ratio (P-LCR) can indicate coronary artery disease risk. Lower P-LCR levels may identify patients with significant coronary artery obstruction, aiding in risk assessment for ischemic heart disease.

Area of Science:

  • Cardiology
  • Hematology
  • Medical Diagnostics

Background:

  • Platelets play a crucial role in thrombosis and cardiovascular events.
  • Understanding platelet behavior is key to managing coronary artery disease (CAD).
  • Platelet indices offer potential biomarkers for cardiovascular risk stratification.

Purpose of the Study:

  • To investigate the relationship between coronary angiographic morphology and various platelet indices.
  • To determine if platelet count, MPV, P-LCR, and PDW correlate with the presence and severity of coronary artery obstruction in ischemic heart disease patients.

Main Methods:

  • Eighty-four ischemic heart disease patients and 120 aged controls were analyzed.
  • Coronary angiography was performed to assess coronary obstruction.
  • Platelet count, mean platelet volume (MPV), platelet-large cell ratio (P-LCR), and platelet distribution width (PDW) were measured from peripheral venous blood.

Main Results:

  • Mean platelet counts were significantly lower in both angiographically positive and negative groups compared to controls.
  • MPV, P-LCR, and PDW were significantly higher in the angiographically negative group compared to both the positive group and controls.
  • Platelet indices in the angiographically positive group were similar to controls, except for platelet count.

Conclusions:

  • Platelet indices can reflect the pathophysiological state and clinical events in patients with ischemic heart disease.
  • A lower P-LCR appears to be a specific indicator for identifying patients with positive coronary angiography findings.
  • These findings suggest the utility of platelet index monitoring in CAD risk assessment.

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