Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Predisposing factors for ventricular arrhythmias.

R W Campbell1

  • 1Freeman Hospital, Newcastle upon Tyne, England.

Journal of Cardiovascular Pharmacology
|January 1, 1991
PubMed
Summary

Reentrant ventricular arrhythmias stem from substrate, trigger, and facilitators. Understanding these interdependent factors is key to controlling arrhythmias and preventing ventricular muscle disease.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Field work services in a residential school for the blind.

Outlook for the blind and the teachers forum·2010
Same author

Effects of surgery for postinfarction ventricular tachycardia on parameters of left ventricular function.

The American journal of cardiology·2002
Same author

Effects of intravenous dofetilide on induction of atrioventricular re-entrant tachycardia.

Heart (British Cardiac Society)·2001
Same author

Thoracoscopic mapping and cryoablation of right ventricular tachycardia.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology·2001
Same author

Time dependent variability of QT dispersion after acute myocardial infarction and its relation to ventricular fibrillation: a prospective study.

Heart (British Cardiac Society)·2000
Same author

Evaluation of antiarrhythmic drug efficacy in patients with an ICD: unlimited potential or replete with complexity and problems?

Journal of cardiovascular electrophysiology·1999

Area of Science:

  • Cardiology
  • Electrophysiology
  • Cardiac Arrhythmias

Background:

  • Ventricular arrhythmias are frequently reentrant in nature.
  • Reentry requires specific conditions within the heart's electrical system.

Purpose of the Study:

  • To elucidate the components contributing to reentrant ventricular arrhythmias.
  • To explore the interplay between substrate, trigger, and facilitatory factors.

Main Methods:

  • Review of existing literature on cardiac electrophysiology and arrhythmia mechanisms.
  • Analysis of the roles of ventricular muscle properties, ectopic beats, and autonomic/biochemical influences.

Main Results:

  • Reentrant arrhythmias depend on a substrate (slow conduction, unidirectional block), triggers (ectopic beats), and facilitators (autonomic tone, electrolytes).
  • Anisotropic conduction, ischemia, and infarction contribute to the substrate but are not solely responsible.
  • Ectopic beat coupling and frequency are critical triggers, with variable coupling potentially more effective.

Conclusions:

  • Substrate, trigger, and facilitator components are interdependent and can influence each other.
  • Future therapies may target these factors for arrhythmia control.
  • Preventing underlying ventricular muscle disease remains the optimal clinical strategy.

Related Experiment Videos