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Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors01:28

Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors

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Male Sexual Response: Erection & Ejaculation01:17

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Related Experiment Video

Updated: Jul 17, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
04:22

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

Vardenafil restores erectile function to normal range in men with erectile dysfunction.

Harin Padma-Nathan1, Francesco Montorsi2, François Giuliano3

  • 1Male Clinic, Beverly Hills, CA, USA;.

The Journal of Sexual Medicine
|January 20, 2007
PubMed
Summary

Vardenafil effectively restored normal erectile function in a significant percentage of men with erectile dysfunction (ED), regardless of ED severity or patient characteristics. This phosphodiesterase type 5 (PDE5) inhibitor therapy offers a viable treatment option for improving erectile function.

Related Experiment Videos

Last Updated: Jul 17, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
04:22

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

Area of Science:

  • Urology
  • Pharmacology
  • Men's Health

Background:

  • Erectile dysfunction (ED) significantly impacts men's quality of life.
  • Oral phosphodiesterase type 5 (PDE5) inhibitors are a key therapeutic class for ED.
  • Restoring normal erectile function is a primary goal of ED treatment.

Purpose of the Study:

  • To evaluate the efficacy of vardenafil in restoring normal erectile function in men with ED.
  • To assess the proportion of patients achieving normal erectile function (IIEF-EF score ≥26) with vardenafil treatment.
  • To analyze treatment outcomes across various patient subgroups based on ED severity, etiology, age, and duration.

Main Methods:

  • Two double-blind, placebo-controlled, parallel-group studies were conducted.
  • Patients received fixed doses of vardenafil (5, 10, or 20 mg) or placebo for 12 or 26 weeks.
  • A retrospective analysis determined the percentage of patients achieving normal erectile function at week 12, with subgroup stratification.

Main Results:

  • Vardenafil doses of 5, 10, and 20 mg resulted in 32%, 43%, and 49% of patients returning to normal erectile function, respectively, compared to 10% for placebo (P < 0.0001).
  • These improvements were observed across all baseline ED severities, etiologies, age groups (including ≥65 years), and durations of ED (including ≥3 years).
  • High success rates (87%-95%) in sexual encounters were reported by patients achieving normal IIEF-EF scores.

Conclusions:

  • Vardenafil significantly improves erectile function, enabling a substantial proportion of men with ED to achieve normal IIEF-EF domain scores.
  • The treatment demonstrates effectiveness across diverse patient populations, including those with severe or long-standing ED.
  • Vardenafil represents an effective therapeutic option for men seeking to restore normal erectile function.