Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Cell-associated complement regulatory proteins and their relation to disease processes].

T Seya1

  • 1Department of Immunology, Center for Adult Diseases, Osaka.

Rinsho Byori. the Japanese Journal of Clinical Pathology
|December 1, 1991
PubMed
Summary

The complement system

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Toll-like receptor 3 in nasal CD103<sup>+</sup> dendritic cells is involved in immunoglobulin A production.

Mucosal immunology·2017
Same author

Human C3b- and C4b-regulatory proteins: a new multi-gene family.

Immunology today·2014
Same author

[Recognition of dsRNA by toll-like receptor 3].

Uirusu·2002
Same author

Three soluble form messages of murine CD46 are produced through alternative mRNA splicing.

Journal of biochemistry·2001
Same author

Elevated serum and cerebrospinal fluid levels of soluble human herpesvirus type 6 cellular receptor, membrane cofactor protein, in patients with multiple sclerosis.

Annals of neurology·2001
Same author

Two receptor theory in innate immune activation: studies on the receptors for bacillus Culmet Guillen-cell wall skeleton.

Archivum immunologiae et therapiae experimentalis·2001

Area of Science:

  • Immunology
  • Biochemistry

Background:

  • Complement system activation is crucial for eliminating foreign materials.
  • Self cells express complement regulatory proteins to avoid C3 attack.

Purpose of the Study:

  • To review the properties of complement regulatory proteins.
  • To discuss the link between diseases and aberrant regulatory proteins.

Main Methods:

  • Literature review of complement system functions.
  • Analysis of complement regulatory proteins (CR1, DAF, MCP).

Main Results:

  • C3 deposition initiates complement activation.
  • CR1, DAF, and MCP protect self cells from complement-mediated damage.
  • Aberrant regulatory proteins are linked to disease processes.

Conclusions:

  • Complement regulatory proteins are essential for self-tolerance.
  • Dysregulation of these proteins contributes to various diseases.

Related Experiment Videos