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Adenosine in burn blister fluid
G Shaked1, R Gurfinkel, D Czeiger
1Department of General Surgery and Trauma Unit, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel. shakedg@bgu.ac.il
Background:
Burn wound blister fluid is known to sustain suppressive effects on various components of the immune system. Damaged tissues cause an increase of adenosine concentrations. Since adenosine is a potent anti-inflammatory agent we hypothesized that burn blister fluid contains high concentrations of this nucleoside.
Methods:
Burn blister fluid was drawn from eleven patients who suffered a second degree burn injury. Adenosine concentrations were determined using high performance liquid chromatography (HPLC).
Results:
Elevated adenosine levels were detected in 6 of the 11 patients (54.5%), with an overall mean of 1.13+/-0.52 mM.
Conclusions:
This is the first documented data showing increased concentrations of adenosine in burn blister fluid.
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