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Updated: Jul 17, 2026

Examination of Oral Candida Infection in Primary Sjögren's Syndrome Patients
Published on: March 1, 2024
Caries-related saliva properties in individuals with 22q11 deletion syndrome
Gunilla Klingberg1, Peter Lingström, Sólveig Oskarsdóttir
1Mun-H-Center, National Orofacial Resource Center, Göteborg, Sweden. gunilla.klingberg@vgregion.se
Objectives:
The aims were to compare saliva secretion rate, buffer capacity, cariogenic bacteria, total protein, IgA, and electrolytes between patients with 22q11 deletion syndrome (22q11DS) and control subjects and to study correlations between saliva and serum levels of IgA and electrolytes in 22q11DS patients.
Study Design:
Twenty-nine consecutive 22q11DS patients (mean age 12.6 years) and matched healthy control subjects were clinically examined, and stimulated saliva samples were collected.
Results:
Patients with 22q11DS had impaired salivary secretion rate (P < .01) and buffer capacity (P < .05), higher numbers of cariogenic bacteria (P < .01), increased saliva protein concentrations (P < .001), and reduced output of electrolytes (P < .001-.05) compared with control subjects. A correlation between concentration in serum and saliva was found only for IgA (r = .622; P < .01).
Conclusions:
Different salivary components were affected in patients with 22q11DS, which may explain the increased caries risk seen in these patients.
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