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Nitrendipine efficacy and safety in patients with mild and moderate essential hypertension
M M Di Salvo1, P M Finocchiaro, M Bonaccorso
1III Divisione Medicina, O.V.E., U.S.L. 35, Catania, Italy.
Insights
Nitrendipine effectively lowers blood pressure in hypertensive patients with type II diabetes or dyslipidemia. This antihypertensive medication demonstrated significant reductions in systolic and diastolic pressures without adverse metabolic effects.
Area of Science:
- Cardiology
- Pharmacology
Background:
- Hypertension is a prevalent condition, often coexisting with metabolic disorders like type II diabetes and dyslipidemia.
- Effective antihypertensive agents are crucial for managing cardiovascular risk in these patient populations.
Purpose of the Study:
- To evaluate the efficacy and safety of nitrendipine as an antihypertensive treatment.
- To assess the impact of nitrendipine on blood pressure in outpatients with mild to moderate hypertension and coexisting type II diabetes or dyslipidemia.
Main Methods:
- A 90-day open-label study involving 29 outpatients with hypertension and either type II diabetes or dyslipidemia.
- Nitrendipine was administered at daily doses ranging from 10 to 40 mg.
- Blood pressure was measured using a Dinamap device before and after the treatment period, following a washout phase.
Main Results:
- Nitrendipine significantly reduced supine blood pressure from 181/99 mm Hg to 148/74 mm Hg and standing blood pressure from 172/104 mm Hg to 143/80 mm Hg.
- No significant changes were observed in heart rate, total cholesterol, HDL cholesterol, or triglycerides.
- Common side effects included headache and flushing in over 20% of patients, but these did not require treatment discontinuation.
Conclusions:
- Nitrendipine is an effective antihypertensive medication for patients with mild to moderate hypertension, including those with type II diabetes or dyslipidemia.
- The drug exhibits a favorable safety profile with no adverse metabolic effects.
- Nitrendipine offers a viable therapeutic option for managing hypertension in complex patient profiles.
Abstract:
The antihypertensive effect of nitrendipine was examined in 29 outpatients with a mild or moderate hypertension and type II diabetes or a dyslipidemic condition. The drug was administered for 90 days at a daily dose of 10 to 40 mg. Following a washout period, the blood pressure (measured by a Dinamap device) was 181/99 mm Hg supine and 172/104 mm Hg standing. Nitrendipine caused a reduction in both pressures and after 90 days their values were 148/74 and 143/80 mm Hg, respectively. Heart rate was not affected by the drug, which also caused no variation in blood pressure, total and HDL cholesterol, and triglycerides. In more than 20% of the cases, treatment was associated with headache and flushing, which did not necessitate discontinuation of treatment. Thus, nitrendipine is an effective antihypertensive agent and causes no untoward metabolic effects.