Related Experiment Video
Updated: Jul 17, 2026
Computed Tomography and Optical Imaging of Osteogenesis-angiogenesis Coupling to Assess Integration of Cranial Bone Autografts and Allografts
Published on: December 22, 2015
Correlation of tuned aperture computed tomography with conventional computed tomography for evaluation of osseous
Madhu K Nair1, Umadevi P Nair, Ali Seyedain
1Oral and Maxillofacial Radiology, University of Florida, Gainesville, FL 32610-0414, USA. nairmk@radiology.ufl.edu
Objective:
To compare the diagnostic efficacy of iteratively restored tuned aperture computed tomography (TACT) with conventional computed tomography (CT) for evaluation of osseous healing in induced calvarial defects.
Study Design:
Fifty-six calvarial defects in 14 rabbits received 1 of 4 possible treatments: copolymer membranes with and without bone marrow stromal cells (BMSCs), BMSCs alone, or no treatment (control). Healing was measured after 2, 4, and 8 wks as remaining defect areas measured on TACT and CT images. Histomorphometric analyses were done on the specimens.
Results:
Bone formation was minimal to none in control defects and those treated with BMSCs or polymer matrices alone. Healthy bone formation was noted in defects treated with polymers impregnated with BMSCs. Unresolved defect area measurements using TACT and CT of osseous healing showed a high positive correlation.
Conclusions:
Potential for TACT to accurately detect osseous healing in surgical defects was demonstrated. High resolution of TACT combined with generation of information in 3D yields comparable performance to CT.
Related Concept Videos
01:10Computed Tomography
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
01:27Imaging Studies III: Computed Tomography