Related Experiment Videos
Low-dose nitrendipine in mild hypertension: a double-blind, placebo-controlled, comparative study
1Medical Unit, Municipal Hospitals, Dortmund, F.R.G.
Journal of Cardiovascular Pharmacology
|January 1, 1991
Summary
Ten milligrams of nitrendipine daily effectively treats mild hypertension. This randomized trial showed significant diastolic blood pressure reduction and higher responder rates compared to placebo, with a good safety profile.
Area of Science:
- Cardiovascular Medicine
- Pharmacology
Background:
- Mild arterial hypertension requires effective and safe treatment options.
- Nitrendipine is a calcium channel blocker used for hypertension management.
Purpose of the Study:
- To evaluate the efficacy and safety of 10 mg of nitrendipine once daily for treating mild hypertension.
- To determine if this dosage is adequate for monotherapy in mild arterial hypertension.
Main Methods:
- Randomized, double-blind, multicenter, placebo-controlled trial over 8 weeks.
- 141 outpatients with mild hypertension received either 10 mg nitrendipine or placebo daily.
- Endpoints included reduction in diastolic blood pressure (DBP) and responder rates.
Main Results:
- Nitrendipine group showed a mean DBP reduction of 11.8 mm Hg vs. 5 mm Hg for placebo.
- Responder rates were 73% for nitrendipine versus 26% for placebo, a statistically significant difference.
- Adverse events were low and comparable between groups; no significant laboratory changes observed.
Conclusions:
- Nitrendipine 10 mg once daily is effective and suitable for monotherapy in mild arterial hypertension.
- The treatment demonstrated a favorable efficacy and safety profile in the studied population.