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Updated: Jul 17, 2026
05:26
Examination of Oral Candida Infection in Primary Sjögren's Syndrome Patients
Published on: March 1, 2024
Congenital candidiasis presenting as septic shock without rash
Kathryn Browning Carmo1, Nick Evans, David Isaacs
1Newborn Care and University of Sydney, Sydney, NSW, Australia. k.carmo@med.usyd.edu.au
Archives of Disease in Childhood
|January 20, 2007
Summary
Congenital candidiasis, a rare fungal infection, can present differently in twins. One twin died from sepsis, while the other survived with a rash, highlighting varied disease severity.
Area of Science:
- Neonatal Medicine
- Infectious Diseases
- Fungal Infections
Background:
- Congenital candidiasis is a rare fungal infection acquired during pregnancy or delivery.
- It is typically considered benign, but severe cases can occur.
Observation:
- A case report details twins born prematurely (32 weeks' gestation) with congenital candidiasis.
- The twins exhibited distinct clinical manifestations and outcomes.
Findings:
- One twin, despite initial well-being and neutropenia, succumbed to overwhelming sepsis and septic shock within 22 hours.
- The second twin developed a delayed rash at 2 days old, remained clinically stable, and survived.
Implications:
- This case underscores the unpredictable and potentially severe spectrum of congenital candidiasis.
- It highlights the importance of vigilant monitoring in neonates, even those presenting with milder symptoms.
- Further research into risk factors and management strategies for severe congenital candidiasis is warranted.
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