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Basic fibroblast growth factor promotes in vivo cerebral angiogenesis in chronic forebrain ischemia
M K Lyons1, R E Anderson, F B Meyer
1Department of Neurological Surgery, Mayo Clinic, Rochester, MN 55905.
Brain Research
|September 6, 1991
Abstract:
This experiment was designed to determine if intraventricular administration of basic fibroblast growth factor (bFGF) could promote cerebral angiogenesis in a model of mild chronic forebrain ischemia. Wistar rats underwent bilateral carotid artery ligation. Animals received intraventricular injections of bFGF every 4 days for 28 days. Basic fibroblast growth factor caused a significant dose-dependent increase in capillary density compared to ischemic controls in all regions examined. These results support the hypothesis that chronic intraventricular administration of bFGF induces in vivo cerebral angiogenesis.