Related Experiment Video
Updated: Jun 26, 2026
11:37
Protocol for MicroRNA Transfer into Adult Bone Marrow-derived Hematopoietic Stem Cells to Enable Cell Engineering Combined with Magnetic Targeting
Published on: June 18, 2018
Clinical side effects during peripheral blood progenitor cell infusion
Ayhan Donmez1, Murat Tombuloglu, Ayse Gungor
1Ege University Medical School Hospital, Department of Internal Medicine, Division of Hematology, Bornova, 35100 Izmir, Turkey. ayhan.donmez@ege.edu.tr
Summary
Side effects during peripheral blood progenitor cell (PBPC) infusions are linked to product volume, DMSO, and TNC content in autologous transplants. Reducing these factors may mitigate infusion-related adverse events.
Area of Science:
- Hematology
- Transplantation Medicine
- Clinical Pharmacology
Background:
- Infusion of peripheral blood progenitor cells (PBPCs) can cause adverse events.
- These side effects may stem from the infusion process or the infusate composition.
Purpose of the Study:
- To evaluate side effects during PBPC infusions.
- To identify factors associated with infusion-related adverse events in autologous and allogeneic transplantations.
Main Methods:
- Retrospective analysis of 194 autologous and 25 allogeneic transplantations.
- Detailed recording of side effects during and after PBPC infusion.
- Statistical comparison of product volume, DMSO, and TNC content between patients with and without side effects.
Main Results:
- 25.25% of autologous PBPC infusions had side effects, with 23.71% occurring during infusion.
- Cardiac side effects (7.73%) necessitated infusion cessation.
- Higher median volume, DMSO, and TNC content were significantly associated with side effects in autologous cryopreserved PBPC infusions.
Conclusions:
- Product volume, DMSO, and TNC content are directly related to clinical side effects in autologous cryopreserved PBPC infusions.
- No infusion-related side effects were observed with allogeneic non-cryopreserved PBPCs.
- Specific infusate parameters influence PBPC infusion safety.
Related Concept Videos
02:45Blood Transfusion and Agglutination
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
01:15Differentiation of Common Myeloid Progenitor Cells
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
01:01Regulation of Hematopoietic Stem Cells
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
01:15Blood Transfusion
Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
01:22Bone Marrow Sampling and Transplants
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...