Related Experiment Video
Updated: Jul 17, 2026
Creation and Transplantation of an Adipose-derived Stem Cell (ASC) Sheet in a Diabetic Wound-healing Model
Published on: August 4, 2017
Enhancing skin wound healing by direct delivery of intracellular adenosine triphosphate
Benjamin Chiang1, Eric Essick, William Ehringer
1Department of Surgery, University of Louisville, Louisville, KY 40202, USA.
Background:
A new intracellular adenosine triphosphate (ATP) delivery technique has been developed and was tested for skin wound care.
Methods:
Eleven pairs of adult nude mice were used. ATP-vesicles were applied in 11 mice, and another 11 mice were treated with lipid vesicles only.
Results:
The group treated with ATP-encapsulated fusogenic small, unilamellar lipid vesicles healed faster than the group treated with only lipid vesicles. Histologic study indicated better developed granular tissue and re-epithelialization in the study group, and wound tissue vascular endothelial growth factor expressions were also higher in ATP-vesicles treated mice.
Conclusions:
This intracellular ATP delivery system may provide a new hope for wound healing as well as the treatment of medical conditions in which ischemia is involved.
Related Concept Videos
01:19Clinical Applications of Epidermal Stem Cells
01:28Phases of Wound Repair
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...