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Keyhole limpet hemocyanin potentiates standard immunotherapy for melanoma

David W McFadden1, Dale R Riggs, Barbara J Jackson

  • 1Department of Surgery, Robert C. Byrd Health Science Center, West Virginia University, Morgantown, WV 26506-9238, USA. dmcfadden@hsc.wvu.edu

American Journal of Surgery
|January 24, 2007
PubMed
Abstract

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...